Scholarly Interests

Dr. Emmanuel Adediran’s research focuses on neuropharmacological modulation of novel brain-targeted Oxytocin and Neuropeptide Y nanoparticle formulation, innovative drug delivery systems and vaccine development. Neuropeptides such as oxytocin and neuropeptide Y are hydrophilic, have a short half-life, and are unable to cross the blood-brain barrier (BBB), limiting their therapeutic potential. To overcome these challenges, Dr. Adediran’s research focuses on the development of clinically translatable novel nanoformulations. His work aims to enhance the delivery and efficacy of neuropeptides by investigating their neuropharmacological modulation through both in vitro and in vivo models for the management of epileptic seizures. Another research interest of Dr. Adediran focuses on using noninvasive delivery systems such as dissolving microneedles and 3D-Printed Oral Dissolving Films, in the delivery of Influenza nanovaccine, effort geared towards global pandemic preparedness. He plays a crucial role as abstract reviewer for National Biotechnology Conference (NBC) and PharmSci360 conferences organized by the American Association of Pharmaceutical Scientist (AAPS). Notably, Dr. Adediran serves on the editorial advisory board of the American Journal of Pharmacotherapy and Pharmaceutical Sciences (AJPPS).

Selected Recent Publications

· Reed SL, Aiani LM, Faiz E, Adediran E, Benveniste M, Murnane KS, et al. Nanoparticle-encapsulated neuropeptide Y provides robust seizure protection in SCN1A-derived epilepsy. Epilepsia. 2025; 00: 1–13. https://doi.org/10.1111/epi.18649

· Adediran, E.; Vijayanand, S.; Kale, A.; Gulani, M.; Wong, J.C.; Escayg, A.; Murnane, K.S.; D’Souza, M.J. Microfluidics-Assisted Formulation of Polymeric Oxytocin Nanoparticles for Targeted Brain Delivery. Pharmaceutics 2025, 17, 452. https://doi.org/10.3390/pharmaceutics17040452

· Adediran, E.; Arte, T.; Pasupuleti, D.; Vijayanand, S.; Singh, R.; Patel, P.; Gulani, M.; Ferguson, A.; Uddin, M.; Zughaier, S.M.; et al. Delivery of PLGA-Loaded Influenza Vaccine Microparticles Using Dissolving Microneedles Induces a Robust Immune Response. Pharmaceutics 2025, 17, 510. https://doi.org/10.3390/pharmaceutics17040510

· Gulani, M.; Arte, T.; Ferguson, A.; Pasupuleti, D.; Adediran, E.; Harsoda, Y.; Nicolas McCommon, A.; Gala, R.; D’Souza, M.J. Recent Advancements in Non-Invasive Vaccination Strategies. Vaccines 2025, 13,978. https://doi.org/10.3390/vaccines13090978

· Adediran E, Ikhoyameh M, Gbadebo OS. From inhibition to degradation: Cutting-edge technology in COVID-19 drug discovery. Ann Pharm Fr. 2025 Aug 6:S0003-4509(25)00118-X. doi: 10.1016/j.pharma.2025.08.002.

· Singh R, Gulani M, Vijayanand S, Arte T, Adediran E, Pasupuleti D, Patel P, Ferguson A, Uddin M, Zughaier SM, D’souza MJ. An intranasal quadruple variant vaccine approach using SARS-CoV-2 and influenza A: Delta, Omicron, H1N1and H3N2. Int J Pharm. 2025 Oct 15;683:126043. doi: 10.1016/j.ijpharm.2025.126043.

Selected Recent Presentations

• Adediran, E.; Arte, T.; Pasupuleti, D.; Vijayanand, S.; Singh, R.; Patel, P.; Gulani, M.; Ferguson, A.; Uddin, M.; Zughaier, S.M.; et al. Development of a Novel Fast Dissolvable Microneedle-Based Delivery System for the Next-Generation Influenza Nanovaccine. 2025 American Association of Pharmaceutical Scientists (AAPS) PharmSci 360 meeting.

• Adediran, E.; Arte, T.; Pasupuleti, D.; Vijayanand, S.; Singh, R.; Patel, P.; Gulani, M.; Ferguson, A.; Uddin, M.; Zughaier, S.M.; et al. Vaccination against Influenza using fast acting 3D Printed Oral Dissolving Films as a Delivery System. 2024 American Association of Pharmaceutical Scientists (AAPS) PharmSci 360 meeting, Salt Lake City, Utah, October 20th to 23rd, 2024.

• Adediran, E.; Vijayanand, S.; Kale, A.; Escayg, A.; Wong, J.; Murnane K.; D’Souza M.J. Assembly of BSA nanoparticles for Brain Targeted Delivery of Oxytocin using a Microfluidics system. 12th Annual Southeastern Pediatric Research Conference. Atlanta, GA, June 2023.

• Adediran, E.; Vijayanand, S.; Kale, A.; Escayg, A.; Wong, J.; Murnane K.; D’Souza M.J. Brain-Targeted Oxytocin Nanoparticles formulated via microfluidics for Epilepsy.2023 American Association of Pharmaceutical Scientists (AAPS) PharmSci 360 meeting, Orlando, FL, October 22nd to 25th, 2023.

• Adediran, E.; Vijayanand, S.; Kale, A.; Escayg, A.; Wong, J.; Murnane K.; D’Souza M.J. Formulation of Brain-Targeted oxytocin-loaded BSA nanoparticles using the microfluidics technology,2023 Southeast Regional Clinical and Translational Science Conference, Pine Mountain, GA, March 1st -3rd 2023

Awards and Honors

2025 – American Association of Pharmaceutical Scientists (AAPS) Best Abstract Award based on innovation and contribution to the field

2025 – National Organization for the Professional Advancement of Black Chemists and Chemical Enginners (NOBCChE) Advancing Science Conference Grant

2025 – Elected Full Member Sigma Xi-Scientific Research Honor Society

2024 – American Association of Pharmaceutical Scientists (AAPS) Best Abstract Award based on innovation and contribution to the field

2023 – Nigerian Association of Pharmacists and Pharmaceutical Scientists in the America (NAPPSA) Scholarship Award

2016 – Femi Oyewo Prize, Best in Clinical Pharmacology, Obafemi Awolowo University

2016 – Egbe Omo Oduduwa Incorporation of Southern Florida Scholarship Award